Dimethyl Sulfoxide
Medchemexpress LLC Dimethyl sulfoxide | 67-68-5 | MFCD00002089 | 100.0% | 78.13 g/mol | C2H6OS | 100mL
Dimethyl sulfoxide (DMSO) is an aprotic solvent that can dissolve water-insoluble therapeutic and toxic agents Dimethyl sulfoxide (DMSO) has a strong affinity for water and has the ability to rapidly penetrate or enhance the penetration of other substances through biological membranes Dimethyl sulfoxide also has potential free radical scavenging and anticholinesterase effects and may affect coagulation activity Dimethyl sulfoxide also induces histamine release from mast cells but is thought to have low systemic toxicity[1] br/ Low endotoxin can be used in various biochemical experiments such as drug dissolution
Apexbio Technology LLC Sotrastaurin (AEB071)(Synonyms: AEB071, Sotrastaurin, PKC inhibitor AEB071, PKC inhibitor Sotrastaurin, Sotrastaurin base, AEB-071), 10mM (in 1mL DMSO), CAS: 425637-18-9.
Sotrastaurin (AEB071 CAS 425637-18-9) is a small-molecule inhibitor targeting protein kinase C (PKC) with inhibitory activity against classical and novel PKC isoforms PKC plays an integral role in immune cell signaling influencing T-cell activation proliferation and cytokine synthesis Sotrastaurin blocks PKC-mediated pathways thereby suppressing T-cell activation proliferation IL-2 mRNA expression and NK-cell function as demonstrated in ex vivo lymphocyte assays Due to its immunoregulatory properties Sotrastaurin has potential therapeutic applications in autoimmune conditions including psoriasis
Apexbio Technology LLC KU-60019 925701-49-1 10mM (in 1mL DMSO)
KU-60019 is a selective inhibitor targeting ataxia telangiectasia mutated (ATM) kinase with an IC50 value of approximately 6 3 nM Through inhibition of ATM kinase activity KU-60019 influences cellular DNA damage responses and sensitivity to radiation therapy It has been demonstrated to enhance radiosensitivity in human fibroblast cells expressing functional ATM but not in ATM-deficient cells Additionally KU-60019 reduces radiation-induced phosphorylation of AKT at Ser473 in glioma cell lines independently affecting cell migration invasion and proliferation KU-60019 serves as an investigational tool for exploring ATM-dependent signaling pathways and examining therapeutic strategies against cancers involving ATM-regulated DNA repair and cell survival mechanisms
Thermo Scientific Production Chemicals and Services DOE AND INGALLS
NC3952589 DIMETHYL SULFOXIDE MULTI 190LT
Apexbio Technology LLC CX-4945 (Silmitasertib) 1009820-21-6 10mM (in 1mL DMSO)
CX-4945 (Silmitasertib CAS 1009820-21-6) is an orally bioavailable inhibitor targeting casein kinase 2 (CK2) via ATP-competitive binding with an IC50 of approximately 1 nM It suppresses CK2-mediated signaling pathways notably by reducing phosphorylation of Akt at Ser129 independently of PTEN activation thus impacting PI3K/Akt pathway regulation In vitro studies report that CX-4945 treatment leads to increased total expression and decreased phosphorylation of cell cycle regulators p21 and p27 causing cell cycle arrest (G2/M in BT-474 breast carcinoma G1 in BxPC-3 pancreatic carcinoma) In vivo it displays antitumor activity in BxPC-3 mouse xenograft models highlighting its utility for oncology research
Apexbio Technology LLC Ketoprofen 22071-15-4 10mM (in 1mL DMSO)
Ketoprofen (CAS 22071-15-4) is a non-steroidal anti-inflammatory drug (NSAID) that inhibits cyclooxygenase enzymes (COX) reducing prostaglandin synthesis and subsequent inflammation In biochemical assays using human recombinant enzymes ketoprofen demonstrates non-selective COX inhibition with reported IC50 values of approximately 0 5 M for COX-1 and 2 33 M for COX-2 Widely utilized in biomedical research ketoprofen serves as a pharmacological tool to investigate inflammatory signaling pathways and evaluate COX-dependent processes
Apexbio Technology LLC Hydroxyurea 127-07-1 10mM (in 1mL DMSO)
Hydroxyurea is a potent inhibitor of ribonucleoside diphosphate reductase a rate-limiting enzyme converting ribonucleotides to deoxyribonucleotides thereby interrupting DNA synthesis and arresting cells in the S-phase of the cell cycle Its reported IC50 values approximate 1 5 mM Hydroxyurea has demonstrated potential in biomedical research settings including inhibition of HIV-1 replication in activated peripheral blood mononuclear cells (PBMCs) with an IC90 of around 0 4 mM induction of fetal hemoglobin (HbF) in erythroid cells from -thalassemia/hemoglobin E patients and tumor growth suppression in various tumor xenograft animal models when used in combination therapy regimens
Apexbio Technology LLC UNC1999(Synonyms: UNC-1999, UNC 1999, EZH2 inhibitor UNC1999, EZH2-IN-UNC1999, EZH2-IN3), 10mM (in 1mL DMSO), CAS: 1431612-23-5.
UNC1999 (CAS 1431612-23-5) is a small molecule inhibitor targeting EZH2 and EZH1 enzymes responsible for methylating lysine 27 on histone H3 (H3K27me3) a modification associated with transcriptional suppression It inhibits EZH2 and EZH1 with IC50 values of 2 nM and 45 nM respectively binding at the enzyme s SAM cofactor binding site but not competing with histone substrate UNC1999 reduces cellular H3K27me3 levels (IC50 124 nM) and inhibits proliferation of DLBCL cells harboring EZH2 Y641N mutation (EC50 633 nM) It exhibits oral bioavailability in mouse studies supporting its utility as a research probe for investigating EZH-mediated epigenetic regulation
Apexbio Technology LLC Brefeldin A(Synonyms: BFA, Ascotoxin, Cyanein, Decumbin, Brefeldin, γ), 10mM (in 1mL DMSO), CAS: 20350-15-6.
Brefeldin A (CAS 20350-15-6) commonly abbreviated as BFA is a small-molecule inhibitor targeting ATPase activity with a reported IC50 of approximately 0 2 M Its primary mechanism of action involves disruption of intracellular vesicle transport by blocking protein trafficking from the endoplasmic reticulum (ER) to the Golgi apparatus and inhibiting GTP/GDP exchange Through these activities BFA reduces ATP-mediated vesicular exocytosis thereby diminishing stimulus-dependent hyperalgesia Additionally it induces endoplasmic reticulum stress and promotes p53 expression in tumor cell models like MCF-7 and HeLa ultimately enhancing apoptosis in colorectal cancer cells (HCT116) BFA is widely employed as a pharmacological tool in cellular biology research to study protein secretion vesicular transport dynamics and ER stress pathways
Apexbio Technology LLC GSK2126458(Synonyms: Omipalisib, GSK-2126458, GSK 2126458, Omipalisib (GSK2126458)), 10mM (in 1mL DMSO), CAS: 1086062-66-9.
GSK2126458 (CAS 1086062-66-9) is a small molecule inhibitor targeting PI3K and mTOR pivotal regulators in cell growth proliferation and tumor progression GSK2126458 demonstrates potent inhibitory activity against PI3K (Ki 19 pM) In colon cancer cells combined use with DDR1-IN-1 enhances its antiproliferative effects Additionally the compound induces G1 phase arrest in BT474 breast cancer cells and sensitizes nasopharyngeal carcinoma (NPC) cell lines to radiation therapy In vivo studies show that combining GSK2126458 with radiation or with MEK and BRAF inhibitors suppresses tumor growth GSK2126458 also influences cellular autophagy pathways highlighting its utility in oncology-focused biomedical research
Apexbio Technology LLC GSK 650394 890842-28-1 10mM (in 1mL DMSO)
GSK 650394 is a small-molecule inhibitor selectively targeting serum- and glucocorticoid-regulated kinase 1 (SGK1) showing inhibition through competitive binding mechanism with an IC50 of approximately 13 nM in fluorescence polarization assays SGK1 functions as an androgen-regulated kinase inhibition of this signaling reduces androgen-driven growth in prostate cancer cell lines Experimental studies demonstrate that GSK 650394 blocks SGK1 and SGK2 kinase activity with IC50 values of 62 nM and 103 nM respectively assessed by scintillation proximity assays Additionally GSK 650394 reduces androgen-induced phosphorylation of SGK substrate Nedd4-2 and suppresses androgen-stimulated proliferation of prostate cancer LNCaP cells (IC50 1 M) suggesting its use in prostate cancer research as a potential therapeutic strategy
Apexbio Technology LLC PF-477736 952021-60-2 10mM (in 1mL DMSO)
PF-477736 is an ATP-competitive small-molecule inhibitor of checkpoint kinase 1 (Chk1) It selectively inhibits Chk1 kinase activity demonstrating nanomolar inhibitory potency in kinase assays and exhibits lower affinity toward related kinases such as CDK1 and Chk2 In vitro studies utilizing human cancer cell lines show PF-477736 disrupts Chk1-dependent G2-phase cell-cycle arrest induced by DNA-damaging agents preferentially targeting tumor cells with compromised p53 function while minimizing cytotoxicity to normal cells PF-477736 is widely utilized experimentally to study DNA damage response mechanisms potential chemosensitizing effects and therapeutic implications for cancers harboring p53 mutations
Apexbio Technology LLC Didanosine 69655-05-6 10mM (in 1mL DMSO)
Didanosine is a nucleoside analogue known to inhibit reverse transcriptase enzymes by acting as a competitive inhibitor and terminator of viral DNA elongation Mechanistically didanosine is phosphorylated intracellularly to its active metabolite dideoxyadenosine triphosphate (ddATP) an analog of dATP Incorporation of ddATP into viral DNA by viral reverse transcriptase causes premature termination of DNA synthesis thereby inhibiting retroviral replication Didanosine is frequently employed as an experimental tool in studies examining antiviral activity and resistance mechanisms in retroviral infection models particularly HIV research In vitro assays commonly report IC50 values for didanosine against HIV reverse transcriptase in the range of approximately 0 5 to 10 M varying according to experimental conditions and viral strain sensitivity evaluated